FEATURES

FAMILY

DESCRIPTION

Also known as DPH5_HUMAN, DPH5. S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DPH5

Diphthine methyl ester synthase

DPH5

Molecular Synopsis