FEATURES

FAMILY

DESCRIPTION

Also known as RETR1_HUMAN, RETREG1, FAM134B, JK1. Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720). Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RETREG1

Reticulophagy regulator 1

RETREG1

Molecular Synopsis