FEATURES

DESCRIPTION

Also known as PKHG2_HUMAN, PLEKHG2. May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PLEKHG2

Pleckstrin homology domain-containing family G member 2

PLEKHG2

Molecular Synopsis