FEATURES

FAMILY

DESCRIPTION

Also known as NAA60_HUMAN, NAA60, HAT4, NAT15. N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27550639, PubMed:27320834). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917). Monomer and homodimer; monomer in presence of substrate and homodimer in its absence (PubMed:27320834).

EXTERNAL LINKS

NAA60

Mutations

Mutation(s) distribution

Mutations table