FEATURES

FAMILY

proton-activated chloride channel family

DESCRIPTION

Also known as PACC1_HUMAN, PACC1, C1orf75, TMEM206. Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH (PubMed:31023925, PubMed:31318332). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925, PubMed:31318332).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PACC1

Proton-activated chloride channel

PACC1

Molecular Synopsis