FEATURES

DESCRIPTION

Also known as MARH7_HUMAN, MARCHF7, AXOT, MARCH7, RNF177. E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MARCHF7

E3 ubiquitin-protein ligase MARCHF7

MARCHF7

Molecular Synopsis