FEATURES

DESCRIPTION

Also known as TBC17_HUMAN, TBC1D17. Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known. Interacts with OPTN.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TBC1D17

TBC1 domain family member 17

TBC1D17

Molecular Synopsis