FEATURES

FAMILY

DESCRIPTION

Also known as PPCS_HUMAN, PPCS, COAB. Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine (PubMed:11923312, PubMed:12906824, PubMed:29754768). Has a preference for ATP over CTP as a cosubstrate (PubMed:11923312). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PPCS

Phosphopantothenate--cysteine ligase

Mutations

Mutation(s) distribution

Mutations table

Search Mutation