FEATURES

FAMILY

DESCRIPTION

Also known as SP30L_HUMAN, SAP30L, NS4ATP2. Functions as transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676)., Functions as transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3., Functions as transcription repressor; its activity is marginally lower than that of isoform 1. Interacts with components of the histone deacetylase complex SIN3A, HDAC1 and HDAC2 (PubMed:16820529). Binds histones and nucleosomes (PubMed:19015240). Interacts with FEZ1 (PubMed:16484223).

EXTERNAL LINKS

SAP30L

Histone deacetylase complex subunit SAP30L

SAP30L

Molecular Synopsis