FEATURES

FAMILY

krueppel C2H2-type zinc-finger protein family

DESCRIPTION

Also known as PATZ1_HUMAN, PATZ1, PATZ, RIAZ, ZBTB19, ZNF278, ZSG. Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:10713105, PubMed:25755280, PubMed:31875552). Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (PubMed:25755280). Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (PubMed:31875552)., (Microbial infection) Plays a positive role in viral cDNA synthesis. Homodimer (By similarity). Interacts with RNF4 (PubMed:10713105). Interacts (via C-terminus) with TP53; this interaction inhibits TP53 ability to activate transcription (PubMed:25755280).

Also known as PATZ1_HUMAN, PATZ1, PATZ, RIAZ, ZBTB19, ZNF278, ZSG. Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell developmen ...

EXTERNAL LINKS

PATZ1

POZ-, AT hook-, and zinc finger-containing protein 1

PATZ1

Molecular Synopsis