FEATURES

FAMILY

DESCRIPTION

Also known as TF7L1_HUMAN, TCF7L1, TCF3. Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. Binds the armadillo repeat of CTNNB1 and forms a stable complex.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TCF7L1

Transcription factor 7-like 1

TCF7L1

Molecular Synopsis