FEATURES

FAMILY

DESCRIPTION

Also known as PCHP_PSEAE, pchP. Catalyzes the hydrolysis of phosphorylcholine (PCho) to produce choline and inorganic phosphate (PubMed:2116592, PubMed:10387109, PubMed:15886911, PubMed:17106798). Can also hydrolyze phosphorylethanolamine and the nonphysiological substrate p-nitrophenylphosphate (pNPP) (PubMed:2116592, PubMed:10387109, PubMed:15886911, PubMed:17106798). Shows higher affinity and catalytic efficiency with phosphorylcholine as substrate (PubMed:2116592)., Is probably involved in virulence (PubMed:19103776, Ref.3). The bacteria may break down various host compounds or host cell membranes through the coordinated action of phospholipase C and phosphocholine phosphatase. The final consequence of the action of these enzymes is an increase of the free choline concentration, which may promote the pathogenicity of P.aeruginosa (Ref.3). Monomer (PubMed:10387109, PubMed:15886911). Homodimer (PubMed:20064618, PubMed:20693680, PubMed:22922065). Homotetramer (PubMed:20693680).

EXTERNAL LINKS

pchP

Phosphorylcholine phosphatase

pchP

Molecular Synopsis