FEATURES

FAMILY

DESCRIPTION

Also known as PVDQ_PSEAE, pvdQ, qsc112. Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis. Heterodimer of an alpha subunit and a beta subunit processed from the same precursor.

EXTERNAL LINKS

pvdQ

Acyl-homoserine lactone acylase PvdQ

pvdQ

Molecular Synopsis