FEATURES

FAMILY

bacterial solute-binding protein PotD/PotF family

DESCRIPTION

Also known as SPUE_PSEAE, spuE. Spermidine-binding protein probably required for its uptake into cells. Binds spermidine with high affinity (KD=14.3 nM). Does not bind putrescine, cadaverine or spermine. Spermidine binding induces large inter-domain conformational changes. Implicated in induction of type 3 secretion systems (T3SS), which play a role in virulence.

EXTERNAL LINKS

uniprot
enzyme classification

spuE

Spermidine-binding periplasmic protein SpuE

spuE

Molecular Synopsis