FEATURES

FAMILY

DESCRIPTION

Also known as EIZFM_STRCO, SCO5223. Involved in the biosynthesis of the sesquiterpenoid antibiotic albaflavenone. Catalyzes the two-step allylic oxidation of epi-isozizaene to albaflavenone. First carries out a non-stereo-specific oxidation of epi-isozizaene to give a mixture of the albaflavenol epimers ((5R)-albaflavenol and (5S)-albaflavenol), each of which can serve as substrate for the second oxidation to yield albaflavenone. This is quite different from most other P450s which catalyze regio- and stereospecific oxidation. Displays also a farnesene synthase activity with farnesyl diphosphate (FPP) as substrate. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

SCO5223

Epi-isozizaene 5-monooxygenase/(E)-beta-farnesene synthase

SCO5223

Molecular Synopsis