FEATURES

FAMILY

DESCRIPTION

Also known as CBH_BIFLN, bsh. Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids). Can hydrolyze the amid bond in all six major human bile salts, namely glycocholate (GCA), glycodeoxycholate (GDCA), glycochenodeoxycholate (GCDCA), taurocholate (TCA), taurodeoxycholate (TDCA) and taurochenodeoxycholate (TCDCA). Shows a slight preference for glycine-conjugated bile acids as substrates (PubMed:10831430, PubMed:16905539). Is totally inactive toward penicillin V (PubMed:16905539). Homotetramer (PubMed:10831430, PubMed:16905539). The tetramer consists of a dimer of dimers (PubMed:16905539).

EXTERNAL LINKS

bsh

Mutations

Mutation(s) distribution

Mutations table