FEATURES

FAMILY

DESCRIPTION

Also known as COCE_RHOSM, cocE. Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants. Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol. Is able to prevent cocaine-induced convulsions and lethality in rat. Homodimer. The protein aggregates upon heat inactivation.

EXTERNAL LINKS

uniprot
enzyme classification

cocE

Mutations

Mutation(s) distribution

Mutations table