FEATURES

FAMILY

DESCRIPTION

Also known as FLNB_RABIT, FLNB. Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton (By similarity). Homodimer. Interacts with FLNA, FLNC, INPPL1, ITGB1A, ITGB1D, ITGB3, ITGB6, MYOT, MYOZ1, PSEN1 and PSEN2. Interacts with MICALL2 (By similarity). Interacts with RFLNA and RFLNB (By similarity). Interacts with HTLV-I viral p13 protein. Interacts with ASB2; the interaction targets FLNB for proteasomal degradation (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

FLNB

Filamin-B

FLNB

Molecular Synopsis