FEATURES

FAMILY

DESCRIPTION

Also known as PGES2_MACFA, PTGES2, PGES2. Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:11866447, PubMed:23426368). The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:23426368). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z), 8(E), 10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (PubMed:23426368). Homodimer (PubMed:15854652). May interact with CEBPB. Interacts with EXOSC10 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

PTGES2

Prostaglandin E synthase 2

PTGES2

Molecular Synopsis