FEATURES

FAMILY

DESCRIPTION

Also known as MED6_CAEEL, mdt-6, med-6. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Acts to repress beta-catenin target genes. Required for asymmetric division of T-cells and for gonad and germ cell development. Component of the Mediator complex (By similarity). Interacts with let-19/mdt-13 (PubMed:15790964). Interacts with RNA polymerase II (PubMed:10611325). Interacts with mdt-28 (PubMed:28603670).

mdt-6

Structural Ligandability

Domains Chains

Distribution