FEATURES

FAMILY

DESCRIPTION

Also known as SPT16_CAEEL, spt-16. Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity). In embryos, promotes cell cycle progression and chromosomal segregation (PubMed:25446273, PubMed:30336114). Plays a role in the development of the anterior pharynx during embryonic development (PubMed:30336114). Component of the FACT complex, a stable heterodimer of spt-16 and hmg-3 or hmg-4.

spt-16

Structural Ligandability

Domains Chains

Distribution