FEATURES

FAMILY

DESCRIPTION

Also known as OAZ_PRIPA, OAZ. Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Interacts with ODC1 and thereby sterically blocks ODC homodimerization.

EXTERNAL LINKS

uniprot
enzyme classification

OAZ

Ornithine decarboxylase antizyme

OAZ

Structural Ligandability

Domains Chains

Distribution