FEATURES

DESCRIPTION

Also known as TRA2_CAERE, tra-2. Plays a major role in controlling sexual cell fates. Promotes female development in XX animals where it sequesters one or more of the FEM proteins to the membrane thereby freeing the tra-1 protein (a putative transcription factor) to enter the nucleus and promote female development. In XO animals it acts as a receptor for her-1 which prevents it from binding to FEM proteins thereby repressing the activity of tra-1. Negatively regulates male development when bound to fem-3 and is required together with tra-1 for promoting spermatogenesis. Interacts with tra-1 and fem-3.

EXTERNAL LINKS

uniprot
enzyme classification

tra-2

Sex-determining transformer protein 2

tra-2

Structural Ligandability

Domains Chains

Distribution