FEATURES

FAMILY

DESCRIPTION

Also known as ABCB9_HUMAN, ABCB9, KIAA1520. ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation (PubMed:15863492, PubMed:17977821, PubMed:18434309, PubMed:22641697, PubMed:25646430, PubMed:30877195, PubMed:31417173, PubMed:30353140). Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers (PubMed:15863492, PubMed:25646430). Binds and transports smaller and larger peptides with the same affinity (PubMed:31417173). Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored (PubMed:15863492, PubMed:17977821, PubMed:18434309). Homodimer (PubMed:15863492, PubMed:30353140). Interacts (via TMD0 region) with LAMP1; this interaction strongly stabilizes ABCB9 and protects ABCB9 against lysosomal degradation (PubMed:22641697). Interacts (via TMD0 region) with LAMP2 (isoform LAMP-2B) (PubMed:22641697). Interacts (via TMD0) with YIF1B; this interaction allows (but is not essential) the ER-to-Golgi trafficking and strongly depends on a salt bridge within TMD0 (PubMed:30877195).

EXTERNAL LINKS

ABCB9

ABC-type oligopeptide transporter ABCB9

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

ABCB9

Structural Ligandability

Domains Chains

Distribution