FEATURES

FAMILY

DESCRIPTION

Also known as DLRB1_HUMAN, DYNLRB1, BITH, DNCL2A, DNLC2A, ROBLD1. Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNLRB2. Interacts with DYNC1I1 and DYNC1I2. Interacts with RAB6A isoform 1 (GTP-bound); the interaction is direct. Interacts with RAB6A isoform 2 (GDP-bound); the interaction is direct. Interacts with RAB6B (GDP-bound).

Also known as DLRB1_HUMAN, DYNLRB1, BITH, DNCL2A, DNLC2A, ROBLD1. Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in ...

EXTERNAL LINKS

DYNLRB1

Mutations

Mutation(s) distribution

Mutations table