FEATURES

FAMILY

DESCRIPTION

Also known as OSGEP_HUMAN, OSGEP, GCPL1. Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes. Interacts with PRAME.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

OSGEP

Probable tRNA N6-adenosine threonylcarbamoyltransferase

OSGEP

Molecular Synopsis