FEATURES

FAMILY

DESCRIPTION

Also known as IL23A_HUMAN, IL23A, SGRF. Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.

EXTERNAL LINKS

IL23A

Mutations

Mutation(s) distribution

Mutations table