FEATURES

FAMILY

DESCRIPTION

Also known as WASH6_HUMAN, WASH6P, CXYorf1, FAM39A. May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Interacts (via WHD1 region) with WASHC2C; the interaction is direct (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

WASH6P

WAS protein family homolog 6

WASH6P

Molecular Synopsis