FEATURES

FAMILY

DESCRIPTION

Also known as BATF3_HUMAN, BATF3, SNFT. AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

BATF3

Basic leucine zipper transcriptional factor ATF-like 3

BATF3

Molecular Synopsis