FEATURES

FAMILY

DESCRIPTION

Also known as CHSTC_HUMAN, CHST12. Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CHST12

Carbohydrate sulfotransferase 12

CHST12

Molecular Synopsis