FEATURES

FAMILY

DESCRIPTION

Also known as C42S2_HUMAN, CDC42SE2, SPEC2. Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CDC42SE2

CDC42 small effector protein 2

CDC42SE2

Molecular Synopsis