FEATURES

FAMILY

DESCRIPTION

Also known as C1GLT_HUMAN, C1GALT1. Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development. Homodimer; disulfide-linked (By similarity). Interacts with the C1GALT1C1 chaperone; required for galactosyltransferase activity.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

C1GALT1

Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

C1GALT1

Molecular Synopsis