FEATURES

FAMILY

DESCRIPTION

Also known as LTBP3_HUMAN, LTBP3. Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex. Interacts with EFEMP2 (PubMed:27339457).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

LTBP3

Latent-transforming growth factor beta-binding protein 3

LTBP3

Molecular Synopsis