FEATURES

FAMILY

DESCRIPTION

Also known as ACS2L_HUMAN, ACSS1, ACAS2L, KIAA1846. Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity). Interacts with SIRT3.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ACSS1

Acetyl-coenzyme A synthetase 2-like, mitochondrial

Mutations

Mutation(s) distribution

Mutations table

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