FEATURES

FAMILY

short-chain dehydrogenases/reductases (SDR) family

DESCRIPTION

Also known as DECR2_HUMAN, DECR2, PDCR, SDR17C1. Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2, 4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2, 4-dienoyl-CoAs, but also towards 2, 4, 7, 10, 13, 16, 19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. Monomer, dimer and oligomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DECR2

Peroxisomal 2, 4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

DECR2

Molecular Synopsis