FEATURES

FAMILY

DESCRIPTION

Also known as UFSP2_HUMAN, UFSP2, C4orf20. Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins (PubMed:25219498, PubMed:32160526). Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (PubMed:25219498). Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (PubMed:25219498). Interacts with DDRGK1 (By similarity). Interacts with TRIP4; deufmylates TRIP4 (PubMed:25219498).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

UFSP2

Ufm1-specific protease 2

UFSP2

Molecular Synopsis