FEATURES

FAMILY

DESCRIPTION

Also known as SMOX_HUMAN, SMOX, C20orf16, SMO. Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SMOX

Spermine oxidase

SMOX

Molecular Synopsis