FEATURES

DESCRIPTION

Also known as PK1IP_HUMAN, PAK1IP1, PIP1, WDR84. Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868). Interacts with PAK1.

Also known as PK1IP_HUMAN, PAK1IP1, PIP1, WDR84. Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PAK1IP1

p21-activated protein kinase-interacting protein 1

PAK1IP1

Molecular Synopsis