FEATURES

DESCRIPTION

Also known as HYPK_HUMAN, HYPK, C15orf63. Component of several N-terminal acetyltransferase complexes (PubMed:20154145, PubMed:29754825, PubMed:32042062). Inhibits the N-terminal acetylation activity of the N-terminal acetyltransferase NAA10-NAA15 complex (also called the NatA complex) (PubMed:29754825, PubMed:32042062). Has chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT in neuronal cells probably while associated with the NatA complex (PubMed:17947297, PubMed:20154145). May play a role in the NatA complex-mediated N-terminal acetylation of PCNP (PubMed:20154145). Component of the N-terminal acetyltransferase A (NatA)/HYPK complex at least composed of NAA10, NAA15 and HYPK, which has N-terminal acetyltransferase activity (PubMed:20154145, PubMed:29754825, PubMed:32042062). Within the complex interacts with NAA10 (PubMed:29754825, PubMed:32042062). Within the complex interacts with NAA15 (PubMed:20154145, PubMed:29754825, PubMed:32042062). Predominantly interacts with NAA15 in the NAA10-NAA15 complex (also called the NatA complex); the interaction with the NatA complex reduces the acetylation activity of the NatA complex (PubMed:29754825, PubMed:32042062). Interacts with HTT (via N-terminus) (PubMed:17947297). The NatA complex is required for HYPK stability and for reducing polyQ aggregation of HTT (PubMed:20154145, PubMed:29754825, PubMed:32042062). Component of the N-terminal acetyltransferase E (NatE)/HYPK complex at least composed of NAA10, NAA15, NAA50 and HYPK (PubMed:32042062). Within the complex interacts with NAA10 and NAA15 (PubMed:32042062). Does not interact with NAA50 (PubMed:29754825, PubMed:32042062). Interaction with NAA15 reduces the capacity of NAA15 to interact with NAA50 (PubMed:29754825, PubMed:32042062). Its capacity to interact with the NatA complex is reduced by NAA50 (PubMed:32042062). Does not interact with the N-terminal acetyltransferase B (NatB) complex component NAA25 or the N-terminal acetyltransferase C (NatC) complex component NAA35 (PubMed:20154145).

EXTERNAL LINKS

HYPK

Huntingtin-interacting protein K

HYPK

Molecular Synopsis