FEATURES

FAMILY

DESCRIPTION

Also known as CP39A_HUMAN, CYP39A1. A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis (PubMed:25201972, PubMed:10748047). Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver (PubMed:25201972, PubMed:10748047). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25201972, PubMed:10748047).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CYP39A1

24-hydroxycholesterol 7-alpha-hydroxylase

CYP39A1

Molecular Synopsis