FEATURES

FAMILY

DESCRIPTION

Also known as CDK12_HUMAN, CDK12, CRK7, CRKRS, KIAA0904. Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. Interacts with CCNL1 and CCNL2 (By similarity). Interacts with CCNK.

Also known as CDK12_HUMAN, CDK12, CRK7, CRKRS, KIAA0904. Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting ...

EXTERNAL LINKS

CDK12

Cyclin-dependent kinase 12

CDK12

Molecular Synopsis