FEATURES

FAMILY

SIGLEC (sialic acid binding Ig-like lectin) family

DESCRIPTION

Also known as SIGL8_HUMAN, SIGLEC8, SAF2. Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (PubMed:10856141, PubMed:10625619). Preferentially binds to alpha-2, 3-linked sialic acid. Also binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619). Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SIGLEC8

Sialic acid-binding Ig-like lectin 8

SIGLEC8

Molecular Synopsis