FEATURES

FAMILY

constitutive coactivator of PPAR-gamma family

DESCRIPTION

Also known as F120A_HUMAN, FAM120A, C9orf10, KIAA0183, OSSA. May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses. Interacts with PURA (By similarity). Interacts with YES1, SRC, FYN. Upon tyrosine phosphorylation, interacts with PIK3R1.

EXTERNAL LINKS

FAM120A

Constitutive coactivator of PPAR-gamma-like protein 1

FAM120A

Molecular Synopsis