FEATURES

FAMILY

DESCRIPTION

Also known as EHF_HUMAN, EHF, ESE3, ESE3B, ESEJ. Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

EHF

ETS homologous factor

EHF

Molecular Synopsis