FEATURES

DESCRIPTION

Also known as LMCD1_HUMAN, LMCD1. Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. Interacts with GATA1 and GATA4 (By similarity). Interacts with beta-dystroglycan. Interacts with GATA6.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

LMCD1

LIM and cysteine-rich domains protein 1

LMCD1

Molecular Synopsis