FEATURES

FAMILY

DESCRIPTION

Also known as PK2L1_HUMAN, PKD2L1, PKD2L, PKDL, TRPP3. Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed:10517637, PubMed:11959145, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:23212381, PubMed:30004384). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration (PubMed:24336289). The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289). Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells (PubMed:19812697). The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again (PubMed:23212381). May play a role in the perception of carbonation taste (By similarity). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (By similarity). Homotetramer (PubMed:25820328, PubMed:30004384). Heterotetramer with either PKD1L1, PKD1L3 or PKD1; the heterotetrameric complex probably contains three PKD1L2 chains plus one chain from another family member (PubMed:25820328, PubMed:23212381). Interacts with PKD1L1, forming a ciliary calcium channel (PubMed:24336289). Interacts with PKD1L3, forming a cation channel that is activated by low extracellular pH (PubMed:25820328, PubMed:23212381). Interacts with PKD1 (By similarity). Interacts with RACK1; inhibits the channel activity possibly by impairing localization to the cell membrane (PubMed:22174419).

Also known as PK2L1_HUMAN, PKD2L1, PKD2L, PKDL, TRPP3. Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed:10517637, PubMed:11959145, Pu ...

EXTERNAL LINKS

PKD2L1

Polycystic kidney disease 2-like 1 protein

PKD2L1

Molecular Synopsis