FEATURES

FAMILY

DESCRIPTION

Also known as RN181_HUMAN, RNF181. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Directly interacts with ITGA2B and, as a result, with integrin ITGA2B/ITGB3. There is no evidence that integrin ITGA2B/ITGB3 is an endogenous substrate for RNF181-directed ubiquitination.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RNF181

E3 ubiquitin-protein ligase RNF181

RNF181

Molecular Synopsis