FEATURES

FAMILY

eukaryotic-type primase small subunit family

DESCRIPTION

Also known as PRIS_PYRFU, priS, priA. Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. Heterodimer of a small subunit (PriS) and a large subunit (PriL). Both participate in formation of the active center, but the ATP-binding site is exclusively located on the small subunit.

EXTERNAL LINKS

priS

DNA primase small subunit PriS

priS

Molecular Synopsis