FEATURES

FAMILY

DESCRIPTION

Also known as VDRA_DANRE, vdra, nr1i1a, vdr. Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding (By similarity). Interacts with ncoa1 and possibly other coactivators, leading to a strong increase of transcription of target genes (PubMed:17218092, PubMed:17346665).

EXTERNAL LINKS

vdra

Vitamin D3 receptor A

vdra

Molecular Synopsis