FEATURES

FAMILY

DESCRIPTION

Also known as POLK_MOUSE, Polk, Dinb1. DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:12432099). Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity). Interacts with PCNA (By similarity). Interacts with REV1 (PubMed:14657033).

EXTERNAL LINKS

uniprot
enzyme classification

Polk

DNA polymerase kappa

Polk

Molecular Synopsis